Stem Cell

Management of Knee Osteoarthritis

This text presents a case series involving four patients with knee osteoarthritis who received a combination therapy of autologous StroMed cell injections, platelet-rich plasma (PRP), and exercise rehabilitation. The treatment resulted in significant improvements in pain, quality of life, and mobility, as assessed by the Knee Injury and Osteoarthritis Outcome Score (KOOS) and physical function tests. The study suggests that this approach may be effective for osteoarthritis patients without pharmaceutical options to halt disease progression.

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Adipose-derived stem cells (ADSCs) and Stromal Vascular Fraction (SVF) Clinical application experiment in skin scar treatment-

Lipofilling is a popular scar treatment method due to the regenerative capacity of adipose-derived stem cells (ADSCs) in the stromal vascular fraction (SVF). A systematic literature search in five databases was conducted to verify the clinical use of ADSC-related interventions in scar treatment. Out of 514 studies, 19 were included in the review, indicating beneficial outcomes in 665 patients. Six studies compared interventions and suggested noninferiority to platelet-rich plasma or CO2 fractional laser.

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Stromal Vascular Fraction on Wound Healing-

This study compared the yield, cell population ratios, and cell viability of SVF isolated by ultrasonic physics (U-SVF) and enzymatic (E-SVF) methods. Both methods had similar stem cell-related characteristics, but U-SVF had a greater number and smaller size of exosome particles.

Trilineage differentiation experiments showed good differentiation ability for both E-SVF and U-SVF. Exosomes secreted by SVF improved fibroblast migration efficiency and upregulated expression of related genes, providing a new therapeutic strategy for soft tissue repair.

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Extracellular vesicles (EVs)-

Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are cell-derived membranous structures that were originally cataloged as a way of releasing cellular waste products.

Many biomolecules carried by EVs have been involved in the control of the hair follicle cycle and stem cell function. Thus, investigating the role of either naturally produced or therapeutically delivered EVs as signaling vehicles potentially involved in skin homeostasis and hair cycling may be an important step in the attempt to design future strategies for the efficient treatment of several skin disorders.

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Osteoarthritis (OA)-

Osteoarthritis (OA) is a leading cause of disability in the world. Mesenchymal stem cells (MSCs) have been studied to treat OA. This review was performed to systematically assess the quality of literature and compare the procedural specifics surrounding MSC therapy for osteoarthritis.

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