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Osteoarthritis

Adding Life to Life
1718865678 St Vincents Treatment 4 1

Aeterna Health's Stem Cell (svCell) Application is a cutting-edge therapy that utilizes live cell clusters to promote healing and rejuvenation. By leveraging the regenerative properties of stem cells, svCell therapies aim to enhance tissue repair, reduce inflammation, and improve overall health and vitality.

What is Osteoarthritis and Symptoms of Osteoarthritis?

Osteoarthritis is a degenerative joint disease causing the breakdown of cartilage and subchondral bone, leading to pain, swelling, and limited mobility. The disease also triggers inflammation that further damages the cartilage. As it progresses, bones can break down and form spurs, and in severe cases, the cartilage may wear away completely, causing bone-on-bone contact.

 

Commonly affected areas include the knee, hip, back, and small joints in the hands and feet, often due to repetitive movements or injuries. Symptoms include persistent joint pain, tenderness, stiffness, locking, loss of motion, and swelling.

Why is osteoarthritis difficult to manage?

  • Progressive Damage: It's a degenerative disease that worsens over time, causing irreversible damage to cartilage and bone.
  • Inflammation: The disease causes inflammation that further damages the joints.
  • Symptom Variability: Symptoms like pain, stiffness, and swelling vary widely, making treatment challenging.
  • Comorbidities: Many patients have other health issues, complicating treatment.
  • Limited Treatment Options: Treatments like NSAIDs offer temporary relief but don't stop disease progression.
  • Pain Management: Chronic pain is hard to manage, and strong painkillers have significant risks.
  • Joint Damage: Severe cases lead to bone-on-bone contact, causing extreme pain and limited mobility.
  • Invasive Treatments: Advanced stages may require surgery, which is risky and requires long recovery.
  • Individual Response: Finding the right treatment combination often involves trial and error.

StemCell(svCell)therapy to treat osteoarthritis

svCell treatment is a cell therapy technology that utilizes adipose-derived stromal vascular fraction (SVF) to treat osteoarthritis and may be offered under medical supervision as an outpatient procedure within an accredited day hospital setting. This form of cell therapy technology is a complementary treatment option for osteoarthritis and has the potential to activate the body’s self-healing ability and generate anti-inflammatory responses that may alleviate osteoarthritis pain, enhance mobility, and encourage cartilage restoration.

 

The objective of svCell therapy for osteoarthritis is to fill the gap between standard pain management options and joint replacement surgery.

How does the StemCell(svCell )work to Treat Osteoarthritis?

svCell is an adipose-derived stromal vascular fraction containing a multipotent heterogeneous mix of regenerative cells that can help reduce inflammation, promote healing mechanisms, and improve tissue repair.

svCell therapy for osteoarthritis has the potential to promote self-healing through the following mechanisms:

  1. Localization of inflammation and injury
  2. Anti-inflammatory and immune-modulatory responses (to reduce pain)
  3. Growth factor secretions promote healing
  4. Stimulating the formation of new blood vessels (angiogenesis)
  5. Promoting chondroprotective effects to delay cartilage degradation (to modify disease progression)
  6. Preserving the joint’s existing cells (anti-apoptosis factors)
  7. Repairing the damaged cartilage layer as well as the bone, tendons, and ligaments
  8. Reduced reliance on anti-inflammatory medications

svCell therapy aims to reduce joint pain and inflammation while maintaining – and in some cases, improving – joint function and reducing stiffness, which may postpone or avoid joint replacement surgery in the future.

StemCell(svCell )therapy effectiveness in the treatment of osteoarthritis.

Pain and Function

Pain and function improvement demonstrated with rapid post-treatment effect, enduring for 60 months.

Changes in the VAS score and the WOMAC score during the 5 years before and after treatment in the SVF group and control group.

A The mean VAS score change. B The mean WOMAC total score changes. *p value <0.05, **p value < 0.01,***p value < 0.001, ns, non-significant (p value > 0.05), compared with pre-treatment.  

1718607548 图片1

Image derived from Zhang et al. 2022

Inflammation

The marked decrease in catabolic and pro-inflammatory molecules (MMP-2, IL-1B, IL-6, IL-8) and a significant increase in anabolic and anti-inflammatory molecules (IGF-1 and IL-10).

Evolution of different markers in knee OA treatment and SVF cell characterization. B.L., Baseline; M, months; black

stars indicate significant differences (p < 0.05, non-parametric Wilcoxon test) Image derived from Lapuente 2020

1718607613 图片2

Image derived from Lapuente 2020

Knee Replacement vs StemCell(svCell )Therapy

In some cases, osteoarthritis treatment may involve surgery (hip joint or knee replacement) to replace the joints. Cell therapy technology may provide an alternative approach for certain patients.

Parameter Knee Replacement svCell Therapy
Impact on bones

Inevitable loss of bone: Tibia,

Femur & Patella

Injection only - no bone loss
Mechanism Prosthesis Natural regenerative cells
Invasion Highly invasive Minimally invasive
Anesthesia General/Spinal Local
Recovery Extended recovery Easier & quicker
Treatment type Artificial implant Autologous cell
Nature of intervention Mechanical Biological
Indication

1. Gr- IV OA

2. Not suitable forRA Patients

3. All Gr. of OA**

4. Suitable for RA also

Revision surgery Difficult with poor outcome Easy
Need for Revision Surgery Generally required after 10-15 years * Need may not be there*
Effect on lifestyle Numerous restrictions Substantial improvement
Hospitalization Minimum stay of 4-5 days Out patient
Implant Rejection Possibility No rejection (as autologous cells used)
Effect on cartilage regeneration It doesn’t treat the underlying cause (i.e. cartilage degeneration) It treats underlying cause by aiding cartilage regeneration and immunomodulation of inflammation
Effect of body weight on outcome Poor result in case of obese patients Effective for all body weights
Age criteria Usually avoided for younger patients Suitable for all age groups
Fitness for surgery

Patients must have good

fitness to undergo this surgery

It is not a major limiting factor

Technical Advantages of Stem Cell (svCell) Therapy

svCell therapy, is an Australian patented biotechnology process, that has been used as a complementary approach to treat osteoarthritis in Australia and the United States for many years.

The potential benefits of using svCell therapy in the clinical treatment of osteoarthritis in Australia include:

as the svCell ultrasonic cavitation process uses a person’s own cells, there is a reduced risk of infection or disease transmission;

as the svCell concentration process does not culture cells, there is no risk of rejection or allergic reaction.

svCell therapy has the potential for therapeutic advantage as it contains a mix of regenerative cells, with some scientific research suggesting that this mixed cell population may provide superior treatment.

Is the Stem Cell(svCell)therapy safe?

Autologous adipose-derived svCell therapy has a reduced risk of adverse reactions or serious side effects.

As the treatment is autologous, with the svCell regenerative cells derived from the patient’s own body, there is a lower risk of infection or disease transmission. Using the patient’s own, uncultured cells reduces potential risks and complications as associated with rejection and allergic reactions.

The ultrasonic cavitation concentration process does not use any enzymes or animal products.. Within a relatively short period of time, potentially within 4 hours, the patient’s cells are concentrated and injected. As a result, there is a reduced chance of infection, disease transmission, bacterial contamination, or allergic reaction.

Over the last 12 years, there has been a body of evidence in peer-reviewed scientific literature supporting the safety of svCell in the treatment of osteoarthritis for knee and hip disease.

What is involved in a StemCell(svCell )therapy procedure?

The svCell therapy procedure involves removing adipose (fat) tissue from the patient’s abdomen, concentrating a mixture of cells, and then re-injecting the cell concentration into the patient’s painful joint(s).

In Australia svCell therapy procedures must be conducted within an accredited hospital setting under medical supervision with patient’s admitted to the hospital as a day surgery patient. The procedure is usually completed within 4 hours after which the patient may go home.

Preparation

Patients taking Aspirin, anti-inflammatory medications (such as Voltaren and Mobic), corticosteroids, or herbal medications (e.g., Krill oil, fish oil, Vitamin E, and Ginkho Biloba) are advised that these must be discontinued at least 10 days before the procedure, according to standard hospital admission instructions. Those patients taking aspirin (Cartia, etc.), clopidogrel (Plavix or Iscover), warfarin, or anticoagulants for a heart condition or stroke prevention, would be provided specific information by their own doctor on when to stop and restart these medications.

Removal of adipose tissue

Patients receive oral sedation, and local anesthetic, and may be prescribed an antibiotic to reduce the risk of infection and are expected to be comfortable, and relatively pain-free.

A syringe or miniliposuction method is used to extract 60-300ml of adipose (fat) tissue from the patient’s abdomen, as that is all that is required. The amount of fat consumed will be determined by the number of joints to be treated. The treating doctor will explain the method of fat extraction to be used prior to the procedure. Because the procedure is minimally invasive, no stitches are usually needed.

Collect regenerative cells

Following adipose tissue removal, a sterile laboratory technician immediately performs the svCell ultrasonic cavitation process to concentrate the patient’s regenerative cells. A flow cytometer is used to count cells and viability and determine the best dosage for the injection of svCell concentrate.

Injection

The injection site is prepared in advance. A Doctor will then inject the svCells into the joint(s).

Where necessary, ultrasound guidance can be used to guide needle placement.

After the injection, patients are monitored for 1 hour before being released to go home.

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Office Address

Suite 1, 990 Toorak Road, Camberwell VIC 3124

Grayclay College of Health
Level 1, 1 Short Street, Southport QLD 4215

+61 3 7016 0801
info@aeternahealth.com.au

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